Facile Synthesis of Hydantoin Derivatives under Microwave Irradiation

In recent years, microwave irradiation using commercial domestic ovens for the optimization and acceleration of organic reactions has rapidly increased1−2.It has been reported that a variety of reactions such as Dielsalder , ene, Claisen reactions , Fischer cyclization, synthesis of heterocycles , hydrolysis of esters , hydrogenation, deprotection of benzyl ester, deacetylation of diacetates, oxazoline formation and polymer synthesis13−17 could be facilitated by microwave irradiation in a good energy transferring medium. Over the last few decades, there has been considerable interest in the synthesis and characterization of hydantoin derivatives as an important class of heterocyclic compounds. Hydantoin derivatives that display interesting activities against a broad range of biological targets have been identified. These compounds are used as anticonvulsants in the treatment of epilepsy and heart arrhythmia. In the chemical industry various 5,5-disubstituted hydantoins constitute the basis of a new generation of weatherproof high-temperaturestable epoxy resins. Furthermore, hydantoin and hydantoin derivatives were used as a monomer for the synthesis of condensation polymers. Recently, we have synthesized a series of new optically active poly(amide-imide)s prepared by the polycondensation reactions of 4,4’-carbonyl-bis(phthaloyl-L−alanine) diacid chloride with 6 different derivatives of hydantoin and thiohydantoin compounds using a domestic microwave oven20−21. We report in this paper a facile method for the synthesis of some hydantoin derivatives under microwave irradiation. ∗Corresponding author